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目的 研究血、尿层粘连蛋白 (LN)与早期糖尿病肾病 (DN)的关系。方法 2型糖尿病 (DM)患者 116例 ,分为正常蛋白尿组 (DMN组 ) 83例 ,微量蛋白尿组 (DMMA组 ) 3 3例 ;对照组 (C组 ) 3 1例。检测尿液LN、白蛋白(Alb)、肌酐 (Cr)和血清LN。结果 ①尿LN/Cr在DMMA组高于C组 (P <0 0 5 ) ;血清LN在DMMA组高于C组及DMN组 (P <0 0 5 )。②DM患者尿Alb/Cr与尿LN/Cr(r =0 183 ,P <0 0 5 )、血清LN(r =0 3 5 7,P <0 0 1)均呈显著的正相关。③DM病程进入了血、尿LN和尿Alb/Cr的回归方程。结论 ① 2型DM患者血、尿LN与尿Alb排出有一致性升高的趋势 ,血清LN是DM早期肾病标志蛋白。②整体DM组中DM病程为血、尿LN和Alb/Cr升高的危险因子。③本研究提示 2型DM患者中血、尿LN水平升高 ,并与DN的发生和严重程度有较好的相关性 ,尿、血LN水平可以用来监测DN的发生、病情进展和治疗效果
Objective To study the relationship between blood, urinary laminin (LN) and early diabetic nephropathy (DN). Methods One hundred and sixty-six patients with type 2 diabetes mellitus (DM) were divided into three groups: normal proteinuria group (DMN group), microalbuminuria group (DMMA group) and control group (group C). Urine LN, albumin (Alb), creatinine (Cr) and serum LN were detected. Results ① The urinary LN / Cr level in DMMA group was higher than that in C group (P <0.05). The level of serum LN in DMMA group was higher than that in C group and DMN group (P <0.05). ② Urine Alb / Cr in DM patients was positively correlated with urinary LN / Cr (r = 0 183, P 0 05) and serum LN (r 0 537, P 0 01). ③ DM course of entry into the blood, urine LN and urine Alb / Cr regression equation. Conclusions ① There is a consistent increase in the excretion of blood and urine LN and urine Alb in type 2 DM patients. Serum LN is a marker of DM early nephropathy. ② The DM course in the whole DM group was a risk factor for elevated blood urea nitrogen and Alb / Cr. ③This study suggests that blood and urine LN levels are elevated in patients with type 2 diabetes mellitus and have a good correlation with the occurrence and severity of DN. Urinary and blood LN levels can be used to monitor the occurrence of DN, the progression of the disease and the therapeutic effect