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牛是产志贺毒素肠出血性大肠杆菌(EHEC)O157:H7菌株的重要贮主,是引起人类出血性结肠炎和溶血尿毒综合征的食物传播的病原体。为了减少人类感染EHECO157:H7的危险,作者进行了EHEC O157:H7对牛的致病性研究。由于从牛或其粪便材料中EHEC O157:H7的分离阳性率低,且通过人工接种EHEC O157:H7发现对≥3周龄的牛不致病,受EHEC O157:H7能使新生的小猪发病的启发,作者从假设
Bovine is an important reservoir of Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) O157: H7 strain and is a food-borne pathogen that causes human hemorrhagic colitis and hemolytic uremic syndrome. To reduce the risk of human infection with EHECO157: H7, the authors conducted a pathogenicity study of EHEC O157: H7 in cattle. Due to the low positive rate of separation of EHEC O157: H7 from cattle or its stool material, and by inoculation of EHEC O157: H7 with EHEC O157: H7, it was found not to be pathogenic to ≥3 weeks old cattle, EHEC O157: H7 was able to cause newborn piglets to develop disease The inspiration, the authors assume