论文部分内容阅读
目的:进一步探讨新型抑癌基因p16与人类卵巢癌发生发展的关系。方法:采用S-P免疫组化方法对母系HO-8910细胞系、高转移HO-8910PM、NSMO模型和转移瘤以及69例卵巢囊腺癌手术标本石蜡组织进行p16检测。结果:母系HO-8910细胞与高转移HO-8910PM细胞、NSMO模型及转移瘤均具有p16阳性表达,表达强度均以转移细胞为弱。69例卵巢癌石蜡组织检测p16阳性51例(占73.9%),结合p16表达有无及强弱与病理组织学类型及分级、临床期别、腹水、癌肿播散、淋巴结转移及5年生存情况比较分析,发现随恶性程度、期别的增加,癌肿播散、淋巴结转移的出现,5年生存率的减低,p16表达明显减少,阳性强度减弱,具有统计学差异(P<0.01)。结论:p16基因不仅为细胞周期的固有调控者,亦与抑制肿瘤生长的关系密切,其缺失与表达水平的改变与卵巢癌的发生发展有关。
Objective: To further investigate the relationship between the novel tumor suppressor gene p16 and the development of human ovarian cancer. METHODS: p16 detection was performed on maternal HO-8910 cell line, high metastasis HO-8910PM, NSMO model and metastases, and 69 paraffin-embedded ovarian cystadenocarcinoma specimens using S-P immunohistochemistry. RESULTS: The maternal HO-8910 cells and highly metastatic HO-8910PM cells, NSMO model, and metastatic tumors all had p16 positive expression, and their expression intensity was weak in metastatic cells. Among the 69 cases of ovarian cancer, paraffin-embedded tissue was detected in 51 cases (73.9%), combined with the presence or absence of p16 expression, histological type and grade, clinical stage, ascites, disseminated cancer, lymph node metastasis, and 5 A comparative analysis of annual survival showed that with the increase of malignancy and stage, the occurrence of cancerous dissemination and lymph node metastasis, the 5-year survival rate was reduced, the expression of p16 was significantly reduced, and the positive intensity was weakened, with statistical significance (P<0). .01). Conclusion: The p16 gene is not only an innate regulator of the cell cycle, but also has a close relationship with the inhibition of tumor growth. The loss and expression levels of p16 gene are related to the occurrence and development of ovarian cancer.