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肥胖能影响机体多种生理机能。有许多研究者报道,胃排空速度与食物成份、体表面积和肥胖有关,但在病理性肥胖者还没有被证实。Wright等以病理性肥胖者和正常受试者对照,观察和比较了胃对固体和液体食物的排空速度。作者选用46名平均体重高于正常标准77%的肥胖者和31名正常非肥胖者,他们均无胃肠道、内分泌异常或植物神经系统疾患史,以年龄、性别和民族作配对指标;固体试餐用~(99)TC标记,液体试餐用~(111)In标记。全部实验持续进行18个月。实验前一天通夜禁食,实验时要求受试者在5min内将试餐吃完,然后用放射核素技术测定食物刚入胃时的放射量为对照。当胃内每种放射核素的放射量降至50%时的时间,即为胃的半排空时间(t1/2),从而推算出胃对固体和液体食物排空速度。
Obesity can affect the body a variety of physiological functions. Many researchers report that gastric emptying rate is related to food composition, body surface area and obesity, but no pathological obesity has yet been confirmed. Wright and other obese and pathological obesity control subjects compared to observe and compare the gastric emptying of solid and liquid food. Forty-six obese individuals with an average body weight greater than 77% of the normal standard and 31 normal non-obese subjects were enrolled. None of them had a history of gastrointestinal tract, endocrine abnormalities or autonomic nervous system disorders, and matched their age, sex and ethnicity. The test meal was labeled with ~ (99) TC, and the liquid test meal was labeled with ~ (111) In. All experiments continued for 18 months. The night before the experiment, fasting overnight, the subjects require subjects to eat the test meal within 5min, and then use radionuclide technology to determine the amount of food fresh into the stomach as a control. When the amount of radioactivity in each of the radionuclides in the stomach drops to 50%, the half-emptying time (t1 / 2) of the stomach is used to calculate the emptying rate of the stomach to solid and liquid foods.