【摘 要】
：
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans,(+)(7S,8S,7\'S,8\'R)iso-magnosalicin(1a)/(-)(7R,8R,7\'R,8\'S)iso-magnosalicin(1b)and(+)(7R,8R,7\'S,8\'R)magnosalicin(2a)/(-)(7S,8S,7\'R,8
【机 构】
：
Institute of Traditional Chinese Medicine&Natural Products,College of Pharmacy/Guangdong Province Ke
论文部分内容阅读
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans,(+)(7S,8S,7\'S,8\'R)iso-magnosalicin(1a)/(-)(7R,8R,7\'R,8\'S)iso-magnosalicin(1b)and(+)(7R,8R,7\'S,8\'R)magnosalicin(2a)/(-)(7S,8S,7\'R,8\'S)magnosalicin(2b),and four known metabolites,(±)acoraminol A(3),(±)acoraminol B(4),asaraldehyde(5),and 2,4,5-tri-methoxybenzoic acid(6).Their structures,including absolute configurations,were determined by extensive analysis of NMR spectra,X-ray crystallography,and quantum chemical ECD calculations.The cytotoxic activity and Aβ42 aggregation inhibitory activity of all the compounds were evaluated.Compound 2 displayed significant anti-Aβ42 aggregation activity with an inhibitory rate of 60.81％(the positive control EGCG:69.17％).In addition,the biotransformation pathway of α-asarone by Alternaria longipes CGMCC 3.2875 was proposed.
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