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治疗绝经后的疾病常用雌激素,由于口服受首过消除影响和产生副作用,故可通过鼻腔给药。本文报道二甲基-β-环糊精和雌二醇(E_2-DMβC)的鼻用配方(DMβC:E_2=1∶2克分子比),溶于96%乙醇中制成包合物,再在50℃和弱的氮气流下将乙醇蒸发。残留物溶于水成所需浓度。兔实验样品是将残留物溶解在含0.9%氯化钠、0.01%洁尔灭、0.1%依地酸钠和2%羟丙基甲基纤维素
Treatment of postmenopausal diseases Commonly used estrogen, oral administration by the nasal cavity due to the elimination of the first pass and the side effects. This paper reports the nasal formulation of dimethyl-β-cyclodextrin and E_2-DMβC (DMβC: E 2 = 1: 2 molar ratio) in 96% ethanol to make the inclusion complex. Ethanol was evaporated at 50 ° C under a weak stream of nitrogen. The residue is dissolved in water to the desired concentration. The rabbit experimental samples were obtained by dissolving the residue in a solution containing 0.9% sodium chloride, 0.01% benzalkonium bromide, 0.1% sodium edetate and 2% hydroxypropyl methylcellulose