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尘肺病是指在工厂农业劳动过程中,长期吸入生产性粉尘所引起的以肺组织纤维化为主的全身性疾病。尘肺病在我国还是一种发病较高,无特效治疗方法,严重危胁人的生命健康的职业性疾病尘肺病被发现距今已有200O余年的历史,但其发病机理目前仍有许多方面不甚清楚。目前,较多的专家和学者认为:尘肺病的肺组织损伤(胶原化),肺泡巨噬细胞膜及细胞内的生物大分子的损伤与吸入的二氧化硅粉尘颗粒导致肺泡巨噬细胞产生的自由基有关,可导致尘肺病人血清脂质过氧化物的超氧歧化酶升高,酮兰蛋白,免疫球蛋白升高。肺泡巨噬细胞膜的主要成份是多聚不饱和脂肪酸,极易受到自由基的攻
Pneumoconiosis is a systemic disease characterized by long-term pulmonary fibrosis caused by long-term inhalation of productive dust in the factory’s agricultural work processes. Pneumoconiosis in our country is still a high incidence of non-effective treatment, a serious threat to human health and occupational diseases, pneumoconiosis has been found over 200 years ago, but its pathogenesis is still there are many aspects Very clear. At present, more experts and scholars believe that: pneumoconiosis lung tissue damage (collagen), alveolar macrophages membrane and intracellular biological macromolecules damage and inhalation of silica dust particles lead to alveolar macrophages free Based on, can lead to pneumoconiosis patients serum lipid peroxide superoxide dismutase increased, kallikrein, immunoglobulin increased. Alveolar macrophages membrane is the main component of polyunsaturated fatty acids, vulnerable to attack by free radicals