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目的 观察成年大鼠双侧卵巢切除对颞下颌关节 (temporomandibularjoint,TMJ)组织学的影响。方法 6 8只 2 0周龄雌性SD大鼠分为 2组 ,用切除双侧卵巢大鼠作为实验组 ,假手术组作为对照组。分别在术后 1、2、4、8和 12周处死动物 ,用光镜、扫描电镜和透射电镜观察大鼠TMJ组织学变化 ,同时检测血清雌二醇 (E2 )和股骨骨密度。结果 各程期实验组血清E2 均明显低于对照组。 12周时 ,实验组大鼠骨密度比对照组明显降低。术后 1、2周 ,大鼠TMJ无明显变化 ,4、8周时可见髁突软骨增厚 ,软骨细胞形态改变等。术后 12周骨质疏松大鼠TMJ可见一系列退行性样改变。结论 大鼠雌激素低下可导致骨质疏松症及TMJ一系列组织学改变 ,骨质疏松症可能与TMJ退行性改变相关
Objective To observe the effects of bilateral ovariectomy on the histology of temporomandibular joint (TMJ) in adult rats. Methods 6 8 20-week-old female Sprague-Dawley rats were divided into two groups, with bilateral ovariectomized rats as experimental group and sham-operated group as control group. Animals were sacrificed at 1, 2, 4, 8 and 12 weeks after operation respectively. The histological changes of TMJ were observed by light microscope, scanning electron microscope and transmission electron microscope. The serum estradiol (E2) and femoral bone mineral density (BMD) Results Serum E2 in experimental group was significantly lower than that in control group. At 12 weeks, the BMD in the experimental group was significantly lower than that in the control group. At 1 week and 2 weeks after operation, there was no significant change in TMJ in rats. At 4 weeks and 8 weeks, condylar cartilage thickening and chondrocyte morphology were observed. After 12 weeks of osteoporosis in rats TMJ visible a series of degenerative changes. Conclusion Low estrogen in rats may lead to a series of histological changes of osteoporosis and TMJ. Osteoporosis may be related to degeneration of TMJ