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目的 :探讨阴黄证血浆内毒素水平以及内毒素血症在阴黄证肝损伤发病机制中的作用。方法 :选用Wistar大鼠 2 4只 ,随机分为正常组、阳黄组及阴黄组。采用生化法测定内毒素含量和丙氨酸转氨酶 (ALT)活性。结果 :与正常组比较 ,阳黄组血浆内毒素水平无显著性差异 ,而阴黄组显著高于对照组 (P <0 .0 1)。阳黄组与阴黄组ALT活性显著高于正常组 ,且阴黄组显著高于阳黄组 (P <0 .0 1)。阴黄组中内毒素水平与ALT活性之间呈正相关关系 (r =0 .993,P <0 .0 1)。结论 :内毒素血症为阴黄证常见并发症 ,内毒素血症在阴黄证肝损伤发病中具有重要作用。
Objective: To investigate the level of plasma endotoxin in Yin-yellow syndrome and the role of endotoxemia in the pathogenesis of liver injury in Yin-Huang syndrome. Methods: Twenty-four Wistar rats were randomly divided into normal group, Yanghuang group and Yinhuang group. Endotoxin content and alanine aminotransferase (ALT) activity were determined by biochemical methods. Results: Compared with the normal group, there was no significant difference in plasma endotoxin level between the positive group and the negative group but higher than that of the control group (P <0.01). The ALT activity of Yanghuang group and Yinhuang group was significantly higher than that of normal group, and the Yinhuang group was significantly higher than that of Yanghuang group (P <0.01). There was a positive correlation between endotoxin level and ALT activity in Yinhuang group (r = 0.993, P <0.01). Conclusion: Endotoxemia is a common complication of Yin-Huang syndrome, and endotoxemia plays an important role in the pathogenesis of liver injury in Yin-Huang syndrome.