论文部分内容阅读
目的:测定人血浆中多潘立酮的浓度,并研究在中国志愿者中单剂量口服20mg后的药物动力学过程.方法:用液-液萃取法提取血浆中药物.采用液相色谱-质谱联用分析手段,建立测定人血浆中多潘立酮浓度的分析方法.结果:多潘正酮在0.52—154.5μg/L浓度范围内线性良好(r=0.9999),其在人血浆中的回收率大于75％,低浓度(0.52μg/L)的日内、日间差异分别为9.4％和7.6％.多潘立酮的血药浓度-经时曲线符合二房室模型,其主要药物动力学参数为:T_(max)=(0.8±0.7)h,C_(max)=(50±32)μg/L,T_(1 2)=(7.8±1.6)h.结论:本方法专属性强,灵敏度高,可准确测定多潘不酮在人血浆中的浓度.
OBJECTIVE: To determine the concentration of domperidone in human plasma and to study the pharmacokinetics of a single oral dose of 20 mg in Chinese volunteers.METHODS: The plasma drug was extracted by liquid-liquid extraction.METHODS: Liquid chromatography-mass spectrometry Means and methods were established to determine the concentration of domperidone in human plasma.Results: Dopantone was linear in the range of 0.52-154.5μg / L (r = 0.9999), and its recovery in human plasma was more than 75% The intra-day and inter-day differences were 9.4% and 7.6%, respectively, at a concentration of 0.52 μg / L. Domperidone’s plasma concentration-time curve fitted the two-compartment model and its main pharmacokinetic parameters were: T max = ± 0.7) h, C max = 50 ± 32 μg / L and T 1 2 = 7.8 ± 1.6 h.Conclusion: The method is characterized by its high specificity and sensitivity and accurate determination of doxorubicin Concentration in human plasma.