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目的探讨三苯氧胺联合米非司酮行药物流产缩短流产后出血时间的可能机制,为临床防治药物流产后出血过多提供理论依据。方法将非意愿妊娠7周内要求药物流产的宫内早孕妇女60例随机分成米非司酮+三苯氧胺组(A组)和米非司酮组(B组),并以30例负压吸宫流产为对照组(C组)。实时定量PCR方法检测绒毛组织中白血病抑制因子(leukemia inhibitory factor,LIF)mRNA的表达。结果A、B、C组绒毛组织中的LIF的mRNA的表达量依次升高。结论米非司酮抑制LIF在绒毛组织的表达可能是其抗早孕机制之一,而三苯氧胺可进一步加强米非司酮的这一作用,这可能是米非司酮联合三苯氧胺缩短药物流产后出血时间的机制之一。
Objective To investigate the possible mechanism of tamoxifen combined with mifepristone in abortion to shorten the bleeding time after abortion and provide a theoretical basis for clinical prevention and treatment of excessive bleeding after medical abortion. Methods Sixty pregnant women with intrauterine pregnancy requiring abortion within 7 weeks of unwanted pregnancy were randomly divided into mifepristone + tamoxifen group (group A) and mifepristone group (group B) Abortion for the control group (C group). Real-time quantitative PCR was used to detect the expression of leukemia inhibitory factor (LIF) mRNA in villi. Results The mRNA expression of LIF in the chorionic tissues of A, B and C groups increased in turn. Conclusion Mifepristone inhibits the expression of LIF in chorion tissue may be one of the mechanisms of anti-early pregnancy, and tamoxifen can further strengthen the role of mifepristone, which may be mifepristone combined with tamoxifen to shorten the time after bleeding medicine One of the mechanisms.