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为探讨ＨＢＶ感染所致的急性肝炎（ＡＨ）、慢性肝炎［慢性活动性肝炎（ＣＡＨ）和慢性迁延性肝炎（ＣＰＨ）］、肝硬化和肝癌中机体免疫能力的改变，以期从调理免疫角度防止该病的进一步恶化。测定了经临床确诊的无症状的ＨＢｓＡｇ携带者２５例，急性病毒性肝炎２０例，慢性活动性肝炎１８例，慢性迁延性肝炎１６例，肝硬化５２例（代偿期２２例，失代偿期３０例），原发性肝癌晚期３２例和正常对照２０例的白细胞介素－２（ＩＬ－２），Ｔ淋巴细胞亚群，可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）和自然杀伤（ＮＫ）细胞活性。结果：无症状ＨＢｓＡｇ患者以上指标与正常对照相比无统计学差异，急性肝炎患者ＣＤ４／ＣＤ８、ＩＬ－２、ＮＫ细胞活性、ｓＩＬ－２Ｒ均明显增高，ＣＡＨ、ＣＰＨ、肝硬化和肝癌患者ｓＩＬ－２Ｒ明显增高，增高趋势为ＣＡＨ＞ＣＰＨ＞肝硬化＞肝癌；ＣＤ４、ＣＤ４／ＣＤ８、ＩＬ－２及ＮＫ细胞活性明显降低。在所有患者中，ＩＬ－２与ＣＤ４／ＣＤ８、ＮＫ细胞活性呈正相关，而与ｓＩＬ－２Ｒ除肝硬化和肝癌患者外均呈负相关。认为感染所致的免疫功能破坏，特别是ＩＬ－２产生的降低可能与ＨＢＶ所致的慢性化及肝癌有一定联系。
In order to explore the changes of immune function in acute hepatitis (AH), chronic hepatitis [chronic active hepatitis (CAH) and chronic persistent hepatitis (CPH)], liver cirrhosis and liver cancer caused by HBV infection, The disease is further worsened. 25 cases of clinically diagnosed asymptomatic HBsAg carriers, 20 cases of acute viral hepatitis, 18 cases of chronic active hepatitis, 16 cases of chronic persistent hepatitis and 52 cases of cirrhosis (22 cases of decompensation, decompensation (N = 30), IL-2, T lymphocyte subsets, soluble interleukin-2 receptor (sIL-2R) in 32 cases of advanced primary liver cancer and 20 cases of normal control Killer (NK) cell activity. Results: There was no significant difference in the above indexes between asymptomatic HBsAg patients and normal controls. The levels of CD4 / CD8, IL-2, NK cell activity and sIL-2R in patients with acute hepatitis were significantly higher than those in normal controls -2R was significantly higher, and the increasing trend was CAH> CPH> cirrhosis> liver cancer. The activity of CD4, CD4 / CD8, IL-2 and NK cells were significantly decreased. In all patients, IL-2 was positively correlated with CD4 / CD8 and NK cell activity, but negatively correlated with both sIL-2R except cirrhosis and liver cancer. It is thought that the destruction of immune function caused by infection, especially the decrease of IL-2 production, may be related to chronic HBV infection and liver cancer.