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目的:分析学龄前儿童氨茶碱中毒的临床特征,为防治氨茶碱中毒提供依据。方法:回顾性分析2002年2月～2010年4月我院收治的9例氨茶碱中毒患儿的实验室检查、影像学检查、临床表现、诊断、治疗措施及用药史资料。结果:医源性因素是学龄前儿童氨茶碱中毒的主要原因,临床主要表现为消化系统损害和中枢神经系统兴奋性增高,检测血液中茶碱浓度是诊断氨茶碱中毒的根本手段。结论:临床医师应严格按照说明书或《中国药典》规定的剂量使用氨茶碱,避免与容易导致茶碱血药浓度升高的药物联合使用。
Objective: To analyze the clinical features of preschool children with aminophylline poisoning and provide basis for the prevention and treatment of aminophylline poisoning. Methods: A retrospective analysis of 9 cases of aminophylline poisoning admitted to our hospital from February 2002 to April 2010 in our hospital was performed on laboratory, imaging, clinical manifestations, diagnosis, treatment and medication history data. Results: The iatrogenic factors were the main cause of aminophylline poisoning in preschool children. The main clinical manifestations were the damage of digestive system and the increase of excitability of central nervous system. Detecting theophylline concentration in the blood was the basic method to diagnose aminophylline poisoning. Conclusion: Clinicians should use aminophylline strictly in accordance with the instructions or the dosage stipulated in Chinese Pharmacopoeia to avoid the combination with drugs that easily lead to the increase of theophylline concentration.