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青光眼是我国致盲率较高的眼病之一,在我国,以原发性闭角型青光眼为最多。此类青光眼的治疗目前仍以窦小梁切除术为主。窦小梁切除术有许多优点,但其主要缺点是术后有相当程度的组织反应和瘢痕形成,这是国内外眼科工作者一直在努力研究的课题。近几年来,我们在此手术中应用α-干扰素,抑制其瘢痕形成,取得良好的效果,现报道如下。 临床资料:自1996年5月至1998年5月在我院手术的原发性闭角型青光眼计51例,随机分为两组。试验组:青光眼患者36例(49眼),年龄在49～75岁之间,其中男性14例(19眼),女性22例(30眼);慢性闭角青光眼17例,急性闭角青光眼19例。对照组:15例(19眼),其中男性7例,女性8例,慢性闭角青光眼7例,急性闭角青光眼8例。年龄在50～71岁之间。 手术方法:术前处置、术后换药及手术方法同一般窦小梁切除术,不同点在剥离完巩膜瓣后,用浸有α-干扰素溶液(浓度为50万u/ml)的棉片置于结膜瓣及巩膜瓣下5分钟(对照组以浸有生理盐水的棉片置于巩膜下5分钟),然后用0.9％氯化钠液10ml冲洗结膜瓣及巩膜瓣,再切除小梁组织。术后随访2年。
Glaucoma is one of the eye diseases with high blindness in our country. In our country, the primary angle-closure glaucoma is the most. The treatment of such glaucoma is still the main sinus trabeculectomy. Trabeculectomy has many advantages, but its main drawback is that there is a considerable degree of tissue reaction and scarring after surgery. This is a topic that ophthalmologists at home and abroad have been working hard to study. In recent years, we applied in this operation α-interferon, inhibit its scarring, and achieved good results, are reported below. Clinical data: 51 cases of primary angle-closure glaucoma operated in our hospital from May 1996 to May 1998 were randomly divided into two groups. In the experimental group, 36 patients (49 eyes) with glaucoma were aged 49 to 75 years old, including 14 males (19 eyes) and 22 females (30 eyes), chronic angle closure glaucoma (17 eyes), acute angle closure glaucoma example. Control group: 15 cases (19 eyes), including 7 males and 8 females, 7 cases of chronic angle-closure glaucoma and 8 cases of acute angle-closure glaucoma. The age of 50 to 71 years old. Surgical methods: preoperative disposal, postoperative dressing and surgical methods the same general trabeculectomy, different points after stripping the scleral flap, with α-interferon solution (concentration of 500000 u / ml) cotton sheet set The conjunctival flap and scleral flap for 5 minutes (control group with saline immersed cotton film placed in the sclera 5 minutes), and then with 10% 0.9% sodium chloride solution, conjunctival and scleral flap rinse, and then remove the trabecular tissue. Follow-up for 2 years.