196 3年Nass等首先发现线粒体是唯一含有独立DNA的细胞器。 1 988年Wallace第 1次发现线粒体DNA(mtDNA)具有突变现象 ,自此mtDNA与疾病的关系得到广泛关注 ;现已知与人类疾病有关的mtDNA突变已达 5 0种以上[1 ] 。因此 ,研究mtDNA与各种疾病之间的关系成为目前基础及临床心脏疾 In 1983, Nass et al. First found that mitochondria are the only organelles that contain independent DNA. In 1998, Wallace discovered for the first time that there was a mutation in mitochondrial DNA (mtDNA). Since then, the relationship between mtDNA and disease has drawn wide attention. More than 50 mtDNA mutations have been reported in human diseases [1]. Therefore, the study of mtDNA and the relationship between various diseases has become the basis and clinical heart disease