论文部分内容阅读
目的 :了解静脉注射 (iv)海洛因依赖者中乙型肝炎病毒 (HBV)、丙型肝炎病毒(HCV)感染状况 ,探讨 HBV、HCV单纯感染和HBV/ HCV重叠感染与丙氨酸转氨酶 (AL T)的关系。方法 :应用 EL ISA法对 2 2 6 0例 iv海洛因依赖者进行血清 HBs Ag、抗 -HCV、AL T检测。结果 :iv海洛因依赖者血清 HBs Ag、抗-HCV阳性率分别为 37.8%、5 3.9% ,HBs Ag、抗 -HCV同时阳性者 45 6例 ,重叠感染率2 0 .2 %均显著高于对照组 (2 4.9%、 2 2 .3%、1 0 .8% )。两组之间的差异有非常显著性 (均 P<0 .0 0 1 )。在 2 2 6 0例 iv海洛因依赖者中 ,HBV、HCV单纯感染者 ,AL T异常率分别为2 6 .3%、5 9.6 % ,两者比较差异有非常显著性(P<0 .0 0 1 )。 HBV/ HCV重叠感染者 AL T异常率 6 2 .1 % ,与 HBV单纯感染者比较 ,差异有非常显著性 (P<0 .0 0 1 ) ,与 HCV单纯感染者比较 ,差异无显著性 (P>0 .0 5 )。结论 :在 iv海洛因依赖者中 ,HCV感染率较 HBV感染率更高 ,抗 -HCV阳性者 ,AL T异常率高于 HB-s Ag阳性者。提示 iv毒品传播 HCV已成为一种不可忽视的重要途径。 AL T的异常与 HCV感染有着密切的关系。
Objective: To investigate the status of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in heroin addicts by intravenous injection (iv) and to investigate the relationship between hepatitis B virus (HCV), simple infection of HCV and HBV / HCV overlap infection with alanine aminotransferase )Relationship. Methods: Serum HBsAg, anti-HCV and ALT were detected in 2660 heroin addicts by ELISA. Results: The positive rates of HBsAg and anti-HCV in the heroin addicts were 37.8% and 53.9% respectively, while 456 cases were positive for HBsAg and anti-HCV. The overlap infection rate was significantly higher than that of the control Group (2 4.9%, 22.3%, 1.08%). The difference between the two groups was significant (P <0. 001). Among 26 6 heroin addicts, the abnormal ALT rates in patients with HBV and HCV infection were 26.3% and 59.6%, respectively, with significant differences (P <0.05) 1 ). The abnormal ALT rate in HBV / HCV co-infected patients was 62.1%, which was significantly different from that in HBV infected patients (P <0.01). There was no significant difference between the two groups P> 0 .0 5). CONCLUSIONS: Among HCV-infected heroin addicts, the prevalence of HCV is higher than that of HBV, and the abnormal rate of ALT is higher in anti-HCV-positive than HB-s Ag-positive. Tip iv Drug transmission of HCV has become an important and can not be ignored. AL T abnormalities and HCV infection are closely related.