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Ｐ１６基因（ＭＴＳ１、ＣＤＫ４Ｉ、ＣＤＫＮ２）是新近发现的一种侯选肿瘤抑制基因，定位于人染色体９ｐ２１，其编码的核磷酸蛋白Ｐ１６１ＮＫ４为ＣＤＫ４的抑制物，参与细胞周期的调节，在食管癌、胰腺癌等消化道肿瘤中有较高的突变率，与人体许多肿瘤的发生、发展有密切关系。本文旨在综述Ｐ１６基因改变与消化道肿瘤发生、发展的关系
The P16 gene (MTS1, CDK4I, CDKN2) is a newly discovered candidate tumor suppressor gene and is located on human chromosome 9p21. The encoded phosphoprotein P161NK4 is an inhibitor of CDK4 and is involved in cell cycle regulation in esophageal cancer, Pancreatic cancer and other digestive tract tumors have high mutation rates and are closely related to the occurrence and development of many human tumors. This article aims to review the relationship between P16 gene mutation and the occurrence and development of digestive tract tumors.