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目的探讨卡介菌多糖核酸联合膦甲酸钠治疗复发性生殖器疱疹患者的临床疗效。方法选取2014年1月至2015年1月吉林省通化市中心医院收治的118例复发性生殖器疱疹患者作为研究对象,采用随机数字表法将其分为观察组及对照组,每组59例。对照组患者予以膦甲酸钠,观察组患者在此基础上采用卡介菌多糖核酸进行治疗,比较两组患者治疗前后外周血T淋巴细胞变化情况、治疗效果及不良反应发生情况,记录观察组治疗前以及治疗后3、6个月临床观察指标变化情况及生命质量。结果治疗后,观察组患者的CD4+、CD4+/CD8+均明显高于对照组,CD8+明显低于对照组,差异均有统计学意义(均P<0.05);治疗后3、6个月观察组患者的复发频率、皮损愈合时间均明显低于治疗前,生理、心理、社会及环境评分均明显高于治疗前,且治疗后6个月相关指标均明显优于治疗后3个月,差异均有统计学意义(均P<0.05);观察组患者治疗的总有效率明显高于对照组,差异有统计学意义。结论采用卡介菌多糖核酸联合膦甲酸钠治疗复发性生殖器疱疹临床疗效明显,可有效提高患者免疫功能,减少复发,同时不会增加不良反应,是一种安全有效的治疗方法。
Objective To investigate the clinical efficacy of BCG polysaccharide nucleic acid combined with foscarnet in the treatment of patients with recurrent genital herpes. Methods A total of 118 patients with recurrent genital herpes admitted to Tonghua Central Hospital from January 2014 to January 2015 were enrolled in this study. The patients were divided into observation group and control group with 59 cases in each group. Patients in the control group were given foscarnet sodium. Patients in the observation group were treated with BCG polysaccharide nucleic acid on this basis. The changes of T lymphocytes in peripheral blood before and after treatment were compared between the two groups. The treatment effect and adverse reactions were recorded. Before treatment, As well as 3,6 months after treatment clinical changes in indicators and quality of life. Results After treatment, the levels of CD4 + and CD4 + / CD8 + in the observation group were significantly higher than those in the control group, and the levels of CD8 + in the observation group were significantly lower than those in the control group (all P <0.05). After 3 and 6 months of treatment, The recurrence frequency and the healing time of skin lesions were significantly lower than those before treatment, the scores of physiology, psychology, social and environmental were significantly higher than those before treatment, and the indexes of 6 months after treatment were significantly better than those of 3 months after treatment (P <0.05). The total effective rate of treatment in observation group was significantly higher than that in control group, the difference was statistically significant. Conclusion The clinical efficacy of BCG polysaccharide nucleic acid combined with foscarnet in the treatment of recurrent genital herpes is obvious, which can effectively improve the immune function and reduce the recurrence of patients without any adverse reactions. It is a safe and effective treatment.