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人们早已知道许多中枢神经系统的有效药物都含芳香环和氮原子,这些基团的特殊分布排列,是止痛药、精神抑制药、抗抑郁药、致幻药、抗惊厥药和兴奋药活性的基本要求。表面上看来其中每一类药物的芳香环和氮原子都存在着基本规律,这导致我们去探索这些基团的分布排列在不同的中枢神经系统药物之间存在什么差别。比较了氯丙嗪、雨咪嗪、苯丙胺、麦角酰二乙胺、安定、苯巴比妥、苯妥英和吗啡等8类中枢神经系统药物中8个典型药物的晶体结构。吗啡和麦角酰二乙胺具有相对刚性的结构。可以假定其晶体结构接近其生理活性
It has long been known that many effective drugs in the central nervous system contain aromatic rings and nitrogen atoms. The special distribution of these groups is the result of analgesic, antipsychotic, antidepressant, hallucinogen, anticonvulsant and stimulant activity basic requirements. On the surface, there is a basic law of the aromatic rings and nitrogen atoms of each of these drugs, which leads us to explore the differences between the distribution of these groups in different CNS drugs. The crystal structures of 8 typical drugs in 8 kinds of central nervous system drugs such as chlorpromazine, mesalamine, amphetamine, lysergic acid, diazepam, phenobarbital, phenytoin and morphine were compared. Morphine and lysergic acid diethylamide have a relatively rigid structure. It can be assumed that its crystal structure is close to its physiological activity