鼠血吸虫病的一个重要免疫现象是调节作用,即在血吸虫感染期自发地减弱肝、肺和结肠粘膜中肉芽肿反应的强度,现在认为其免疫病理的基础是一种迟发型超敏反应。作者将日本血吸虫(Kofu株)卵注入小鼠肠系膜上静脉诱导耐受性。在门静脉致敏后两周ddY雄鼠背外侧皮下注射加等量福氏完全佐剂的血吸虫卵,7天后在鼠左后足垫注射虫卵PBS液,抗原注射后24h观察足垫肿胀反应。为了确定小鼠足垫肿胀反应是否随血 An important immunological phenomenon in mouse schistosomiasis is the regulatory effect of spontaneously attenuating the intensity of granulomatous reactions in the liver, lung and colon mucosa during the schistosomal infection phase, and is now believed to be based on a delayed type hypersensitivity reaction. The authors injected Schistosoma japonicum (Kofu strain) eggs into the superior mesenteric vein of mice to induce tolerance. Two weeks after portal vein sensitization, ddY male mice were dorsolateral injected subcutaneously with equal doses of Freund’s complete adjuvanted Schistosoma japonicum eggs. After 7 days, they were injected with PBS solution on the left hind footpad, and footpad swelling reaction was observed 24h after antigen injection. In order to determine whether the mouse foot pad swelling reaction with the blood