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本研究旨在探讨非小细胞肺癌(NSCLC)Ⅰ~Ⅲ期患者术后5年生存率的影响因素。我们收集了2009年1月至2009年12月间经组织学证实的腺癌或鳞状细胞癌的NSCLC术后患者共220例,且存活期大于3个月。影响因素有多个变量,如年龄、性别、吸烟、酒精、肥胖、糖尿病、高血压、抗糖尿病药物、肿瘤分期、病理学、治疗方式、发病部位(左侧或右侧)以及脂质水平。通过单变量分析,我们发现肿瘤分期与Ⅰ~Ⅲ期NSCLC患者的5年生存率相关。此外,糖尿病、高血压和发病部位(左侧或右侧)分别与NSCLC患者Ⅰ期,Ⅱ期和Ⅲ期的5年生存率相关。由此可得,慢性病及其治疗药物可能对肺癌患者术后5年生存率具有潜在影响。
This study aimed to investigate the influencing factors of 5-year survival rate in patients with stage Ⅰ-Ⅲ non-small cell lung cancer (NSCLC). We collected a total of 220 NSCLC patients with histologically confirmed adenocarcinoma or squamous cell carcinoma between January 2009 and December 2009 with a median survival of more than 3 months. There are a number of variables affecting age, gender, smoking, alcohol, obesity, diabetes, hypertension, antidiabetic drugs, tumor staging, pathology, treatment modalities, site of disease (left or right) and lipid levels. By univariate analysis, we found that the tumor stage was related to the 5-year survival rate of stage I-III NSCLC patients. In addition, diabetes, hypertension, and site of disease (left or right) were associated with 5-year survival rates for stage I, II, and III NSCLC patients, respectively. Thus, chronic diseases and their therapeutic drugs may have a potential impact on the 5-year survival rate of patients with lung cancer.