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目的：研究雄性激素对杜氏利什曼原虫感染的Ｃ５７ＢＬ／６Ｊ小鼠骨髓巨噬细胞（ＢＭＭｓ）水平的影响。方法：用雄性激素处理小鼠３ｗｋ后，收集ＢＭＭｓ，培养５ｄ后，按ＢＭＭｓ前鞭毛体＝１１０的比例，接种杜氏利什曼原虫，用吉姬氏染色法观察不同时相的感染水平。结果：与植物油处理的对照组相比，雄性激素处理的小鼠ＢＭＭｓ对前鞭毛体较为易感，并随着感染时间的延长其感染水平增高（感染后３ｈ，Ｐ＜０．０５；２４ｈ，４８ｈ和７２ｈ，Ｐ＜０．０１）。结论：雄性激素可增加杜氏利什曼原虫对ＢＭＭｓ的感染水平，这可能与雄性激素诱导的免疫抑制作用有关
Objective: To investigate the effect of androgen on the level of bone marrow macrophage (BMMs) in Leishmania donovani infected C57BL / 6J mice. Methods: After being treated with androgen for 3 weeks, BMMs were collected and cultured for 5 days. Leishmania donovani was inoculated according to the proportion of BMMs promastigotes = 110, and the infection levels in different phases were observed with Jigerian staining. RESULTS: Compared with the vegetable oil-treated control group, the androgen-treated mouse BMMs were more susceptible to the promastigotes and had an increased infection with prolonged infection (3 h post-infection, P <0.05; 24h, 48h and 72h, P <0.01). Conclusion: Androgen can increase the level of BMMs infection in Leishmania donovani, which may be related to androgen-induced immunosuppression