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除遗传性血红蛋白病外,在某些疾病过程中继发出现的血红蛋白(简称 Hb)组成异常,即获得性血红蛋白病,已引起了不少学者的重视,人们为此作了大量的研究。原因在于:①可能对一些疾病的诊断、鉴别诊断或预后有意义;②可能揭示一些疾病特别是血细胞恶性增生性疾病发病学的某些方面;③可能获得有关血红蛋白合成调控机制的知识,进而寻求遗传性血红蛋白病的治疗途径。现扼要综述如下。
In addition to hereditary hemoglobinopathies, abnormal hemoglobin (referred to as Hb) secondary to some disease processes, ie, acquired hemoglobinopathies, has attracted the attention of many scholars and many people have done a lot of research on it. The reason is: ① may be some of the diagnosis of the disease, differential diagnosis or prognosis of meaningful; ② may reveal some diseases, especially in some aspects of the pathogenesis of hematopoietic malignant disease; ③ may obtain knowledge about hemoglobin synthesis and regulation mechanisms, and then seek Hereditary hemoglobin disease treatment. The summary is as follows.