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真核细胞翻译起始因子4E(eIF4E)是最重要的翻译起始因子,在真核细胞蛋白质合成中起重要作用。近年来研究显示,eIF4E过表达与肿瘤的发生发展关系密切。与正常组织及良性肿瘤相比较,发现很多恶性肿瘤和肿瘤旁组织中eIF4E过度表达,并与肿瘤的侵袭转移能力呈正相关。研究发现,eIF4E通过多方面调控恶性肿瘤相关mRNAs的翻译,包含细胞有丝分裂过程、激活原癌基因、血管形成、增强自分泌、细胞存活、侵袭及与细胞外环境的交通。eIF4E与肿瘤的密切关系为临床治疗肿瘤提供了新思路,更有可能成为肿瘤治疗的共同靶点和肿瘤发展与预后的预测因子。
Eukaryotic translation initiation factor 4E (eIF4E) is the most important translation initiation factor and plays an important role in eukaryotic protein synthesis. In recent years, studies have shown that, eIF4E overexpression and tumor occurrence and development are closely related. Compared with normal tissues and benign tumors, eIF4E was found to be overexpressed in many malignant and paracancerous tissues and positively correlated with tumor invasion and metastasis. The study found that eIF4E regulates the translation of malignant tumor-associated mRNAs in many ways, including cell mitosis, activation of proto-oncogene, angiogenesis, enhancement of autocrine, cell survival, invasion and communication with the extracellular environment. The close relationship between eIF4E and tumor provides new ideas for the clinical treatment of tumors and is more likely to become a common target for tumor therapy and a predictor of tumor development and prognosis.