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目的观察重组人生长激素用于烧伤治疗的临床效果。方法选取烧伤患者88例,随机分为观察组与对照组各44例。植皮术后予2组患者常规抗感染治疗与相应的营养支持。观察组在此基础上于手术结束第3天予重组人生长激素皮下注射治疗,观察、比较2组临床指标改善情况、体内PA、Tb含量变化及创面愈合时间。结果与治疗前比较,2组生长激素、血糖以及胰岛素等3项临床指标均有改善,观察组改善情况优于对照组(P<0.05);2组PA、Tb含量均升高,观察组升高幅度大于对照组(P<0.01);观察组植皮区愈合时间、供皮区愈合时间及深Ⅱ度痂下愈合时间均短于对照组(P<0.01)。结论重组人生长激素用于烧伤治疗,能明显改善患者临床指标,提高患者PA、Tb含量,缩短创面愈合时间,效果良好,值得推广应用。
Objective To observe the clinical effect of recombinant human growth hormone for burn treatment. Methods Eighty-eight burn patients were randomly divided into observation group and control group, 44 cases each. Two groups of patients after skin grafting routine anti-infective treatment and the corresponding nutritional support. On the basis of this observation, the observation group was treated with recombinant human growth hormone subcutaneously on the third day after surgery. The improvement of clinical indexes, changes of PA, Tb content and wound healing time in the two groups were observed and compared. Results Compared with those before treatment, the two clinical indexes of growth hormone, blood glucose and insulin were all improved, and the improvement in the observation group was better than that in the control group (P <0.05). The contents of PA and Tb in the two groups were all increased, (P <0.01). The healing time of the skin graft in the observation group, the healing time in the donor area and the healing time in the deep second degree scab were shorter than those in the control group (P <0.01). Conclusion Recombinant human growth hormone can be used to treat burn patients. It can significantly improve the clinical indexes, improve PA, Tb content and shorten the wound healing time. It is worth to be popularized and applied.