【摘 要】
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Dear Editor,Fibroblast growth factors (FGFs) regulate a plethora of critical processes in development (Beenken and Mohammadi,2009).These processes are mediated
【机 构】
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Department of Biochemistry, University of Cambridge,Cambridge CB2 1GA, UK
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Dear Editor,Fibroblast growth factors (FGFs) regulate a plethora of critical processes in development (Beenken and Mohammadi,2009).These processes are mediated by signaling through four FGF receptors (FGFR1-4),which are high-affinity cell surface receptor tyrosine kinases.Receptors 1-3 undergo alteative splicing to generate b-and c-isoforms with altered ligand specificities and affinities.Ligand to receptor binding is not unique and one receptor can be activated by several FGFs.Heparan sulfate (HS) proteoglycan,a variably polysulfated glycosaminoglycan related to heparin,is an essential requirement for FGF signaling with FGFs varying in their specificities for different HS sulfation pattes (Gallagher et al.,1992).
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