滴眼剂如有刺激性,可损伤眼部组织或导致泪液分泌增多而冲去药物,影响临床用药的安全与有效。早在1944年Draize就提出了滴眼剂的刺激性试验法,小川俊太郎等还评述了有关的研究工作,所用方法都是通过观察眼部组织受损伤的程度(如结膜充血、睫状充血、泪液分泌等,并应用萤光素钠观察角膜透明度的变化)来检查测定滴眼剂刺激性的 Eye irritation, if any, can damage the eye tissue or lead to increased secretion of tear and rushed to the drug, affecting the safety and effectiveness of clinical medication. As early as 1944, Draize proposed the eye irritation test method, and Dr. Ogawa also reviewed the research work, the methods used are by observing the extent of damage to the ocular tissue (such as conjunctival hyperemia, ciliary congestion, Tear secretion, etc., and the use of sodium fluorescein observation of changes in corneal transparency) to examine the determination of eye irritation