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目的探讨白三烯E4(LTE4)在支气管哮喘(简称哮喘)发病机制中的作用。方法用ELISA法对急性发作期和非急性发作期哮喘患者各20例及健康志愿者15名作尿液LTE4测定。结果哮喘急性发作组、非急性发作组尿液LTE4明显高于正常对照组(P<0.01)。哮喘急性发作组尿液LTE4值又明显高于非急性发作组(P<0.01)。哮喘非急性发作者用白三烯受体拮抗剂治疗后可使尿液LTE4水平明显降低。结论本研究结果表明白三烯在哮喘发病中起了重要的作用,检测尿液LTE4水平对于了解哮喘患者体内白三烯水平,以及评价白三烯受体拮抗剂的疗效具有一定的临床意义。
Objective To investigate the role of leukotriene E4 (LTE4) in the pathogenesis of bronchial asthma (asthma). Methods Twenty patients with acute asthmatic and non-acute exacerbation asthma and 15 healthy volunteers were enrolled in this study. Results The urinary excretion of LTE4 in acute exacerbation group and non-exacerbation group was significantly higher than that in normal control group (P <0.01). Urinary LTE4 values in the acute asthma attack group were significantly higher than those in the non-acute attack group (P <0.01). Non-acute asthmatic patients treated with leukotriene receptor antagonist can significantly reduce the level of urine LTE4. Conclusions The results of this study indicate that leukotriene plays an important role in the pathogenesis of asthma. Detection of urinary LTE4 level is of clinical significance in understanding leukotriene levels in asthma patients and evaluating the efficacy of leukotriene receptor antagonists.