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作者等在各种动物身上进行了组胺受体的分型研究。已明确气管、支气管的收缩是H_1受体占优势,但也存在一定量的H_2受体参与支气管扩张或对支气管收缩起着调节作用。晚近,又研究了组胺对各种种属动物气管和支气管的作用。结果归纳为二大类:一类对组胺可产生支气管痉挛(即阳性反应者,如人、豚鼠、狗、马、牛);另一类对组胺显示支气管扩张或根本无反应(即阴性反应者,如羊、猫、兔、大鼠和雪貂)。作者对上述各种属动物(不包括人)气道平滑肌用足够量的新安替根预先处理以阻滞H_1受体的气管收缩作用,再用氨甲酰胆碱、5-HT或慢反应物质使其产生
The authors carried out histone receptor typing studies on various animals. It is clear that tracheal, bronchial contraction is the dominant H_1 receptor, but there are also a certain amount of H_2 receptors involved in bronchiectasis or bronchoconstriction play a regulatory role. Recently, the effect of histamine on the trachea and bronchi of various species of animals has also been studied. The results were grouped into two broad categories: one class produces histamine that produces bronchospasm (ie, positive responders such as humans, guinea pigs, dogs, horses, cattle); the other class shows no bronchodilation or no response to histamine (ie, negative Responders, such as sheep, cats, rabbits, rats, and ferrets). The authors pre-treated airway smooth muscle cells of various species of animals (excluding humans) with a sufficient amount of new anti-tigen to block the tracheal constriction of the H 1 receptor followed by carbachol, 5-HT or a slow-reacting substance Make it happen