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目的了解性病门诊患者人乳头瘤病毒(HPV)的感染情况及其基因型别。方法用导流杂交分型检测法对1 516例性病门诊患者进行HPV检测与基因分型,评价HPV及其基因型别与疾病类型的关系。结果 1 516例受检者中,HPV总阳性率为55.61%。基因型分析发现,26例鲍温病样丘疹病患者均有高危型HPV感染,而762例尖锐湿疣患者中低危型HPV感染占70.86%。21种HPV基因型均被检出,以HPV6(28.86%)、11(17.23%)、16(10.41%)型感染最为常见。检出的843例阳性患者中单一型别感染占61.68%,以HPV6和HPV11感染为主;HPV多重感染以高低危型HPV混合感染为主。结论 HPV基因型别分布与疾病类型密切相关,HPV亚型的鉴别对相关疾病的预防和治疗具有临床应用价值。
Objective To understand the infection and genotypes of human papillomavirus (HPV) in STD clinics. Methods A total of 1 516 cases of STD clinics were tested for HPV detection and genotyping by flow-guide hybridization (IHC). The relationship between HPV genotypes and disease types was evaluated. Results Among the 1 516 cases, the total positive rate of HPV was 55.61%. Genotype analysis found that 26 cases of Bowen’s disease papulosis patients have high-risk HPV infection, and 762 cases of genital warts in low-risk HPV infection accounted for 70.86%. Twenty-one HPV genotypes were detected, with HPV6 (28.86%), 11 (17.23%), 16 (10.41%) infection the most common. Among the 843 positive patients detected, 61.68% of them were single type infection, with HPV6 and HPV11 infection as the main ones. Multiple HPV infections were mainly mixed with high and low risk type HPV. Conclusion The distribution of HPV genotypes is closely related to the type of disease. The identification of HPV subtypes is of clinical value in the prevention and treatment of related diseases.