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系统探讨α－２ｂ干扰素在呼吸道感染儿对阳性的柯萨奇Ｂ组病毒抗原（ＣＶＢ－Ａｇ）的消除效应。ＣＶＢ－Ａｇ阳性呼吸道感染病儿３８例，其中上呼吸道感染１６例，下呼吸道感染２２例，年龄２～１０岁，平均４．５５＋３．８１岁，男２１例，女１７例。分Ａ（１８例），Ｂ（２０例）２组。ＣＶＢ－Ａｇ和ＣＶＢ－ＩｇＭ测定采用ＥＬＩＳＡ法。α－２ｂ干扰素，皮下或肌肉注射５～７天，每天１００万Ｕ。连续３周观测２组ＣＶＢ－Ａｇ阳性率变化，并分析ＣＶＢ性心肌炎发生率。结果显示：（１）用α－２ｂ干扰素后１～２周抗原阳性率明显降低（Ｐ＜０．０５）。（２）用α－２ｂ干扰素后ＣＶＢ性心肌炎发病率明显降低（Ｐ＜０．０１）。（３）α－２ｂ干扰素不良反应轻。提示α－２ｂ干扰素有快速消除ＣＶＢ抗原的功效，并对降低ＣＶＢ性心肌炎的发病有益。
To investigate the elimination effect of α-2b interferon on the positive Coxsackie B virus antigen (CVB-Ag) in children with respiratory tract infection. There were 38 cases of CVB-Ag positive respiratory infection, including 16 cases of upper respiratory tract infection and 22 cases of lower respiratory tract infection. The average age was from 2 to 10 years old, with an average of 4.55 + 3.81 years. There were 21 males and 17 females. Points A (18 cases), B (20 cases) 2 groups. The CVB-Ag and CVB-IgM assays were performed by ELISA. Alpha-2b interferon, subcutaneous or intramuscular injection of 5 to 7 days, 1 million U per day. The changes of positive rate of CVB-Ag in 2 groups were observed for 3 consecutive weeks, and the incidence of CVB myocarditis was analyzed. The results showed that: (1) The positive rate of antigen in 1-2 weeks after treatment with α-2b interferon was significantly lower (P <0.05). (2) The incidence of CVB myocarditis was significantly lower with α-2b interferon (P <0.01). (3) α-2b interferon adverse reactions. Tip α-2b interferon has a rapid elimination of CVB antigen efficacy, and reduce the incidence of CVB myocarditis beneficial.