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目的:观察十全大补汤加减治疗奥沙利铂致神经毒性临床疗效。方法:将42例患者随机分为治疗组22例,对照组20例,2组患者均采用奥沙利铂联合化疗方案。治疗组在对照组化疗基础上加用十全大补方,水煎服,1剂/d,于用奥沙利铂前2天开始口服,12天为1个周期,连服2周期。化疗结束后继续观察随访6个月。结果:治疗组痊愈7例,占31.82%;有效12例,占54.55%;无效3例,占13.64%;总有效率86.36%。对照组痊愈3例,占15.00%;有效10例,占50.00%;无效7例,占35.00%;总有效率65.00%。2组总有效率比较有显著性差异(P<0.05),治疗组疗效优于对照组。结论:十全大补汤加减治疗奥沙利铂致神经毒性疗效显著。
OBJECTIVE: To observe the clinical efficacy of Shiquan Dabu decoction in the treatment of oxaliplatin-induced neurotoxicity. Methods: Forty-two patients were randomly divided into treatment group (n = 22) and control group (n = 20). Both groups were given oxaliplatin combined with chemotherapy. The treatment group in the control group on the basis of chemotherapy plus Shiquan Da Fang, Shuijianbi, 1 / d, with oxaliplatin 2 days before oral administration, 12 days for a cycle, and even for 2 cycles. Follow-up after chemotherapy for 6 months. Results: The treatment group cured in 7 cases, accounting for 31.82%; effective in 12 cases, accounting for 54.55%; invalid in 3 cases, accounting for 13.64%; the total effective rate was 86.36%. The control group recovered 3 cases, accounting for 15.00%; effective in 10 cases, accounting for 50.00%; invalid in 7 cases, accounting for 35.00%; the total effective rate was 65.00%. The total effective rate of the two groups was significantly different (P <0.05), the treatment group than the control group. Conclusion: Decoction of Shiquandabu Decoction can significantly induce the neurotoxicity induced by oxaliplatin.