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目的探讨合并糖调节受损早发稳定型冠心病(PSCHD)患者(<50岁)循环炎症指标与动脉粥样硬化(AS)特征。方法将208例PSCHD患者分为糖调节正常(NGR)组和糖调节受损(1GR)组,分析其临床和生化资料。结果 1GR组的BMI、TG、尿酸(UA)、高敏C反应蛋白(hsC-RP)、WBC计数、颈动脉内膜中层厚度(IMT)值和斑块比例、代谢综合征和高血压患病率、冠状动脉斑块积分以及多支病变比例均高于NGR组;hsC-RP与WBC计数、BMI及TG正相关,与HDL-C负相关;WBC计数与BMI及UA正相关;P均<0.05或<0.01。结论合并IGR的PSCHD患者循环炎症指标和AS程度均显著增加。
Objective To investigate the relationship between circulating inflammatory markers and atherosclerosis (AS) in patients with stable spontaneous coronary artery disease (PSCHD) (<50 years old). Methods 208 patients with PSCHD were divided into normal glucose regulation (NGR) group and impaired glucose regulation (1GR) group, and their clinical and biochemical data were analyzed. Results The BMI, TG, UA, hsC-RP, WBC count, carotid artery intima-media thickness (IMT) and plaque ratio, metabolic syndrome and the prevalence of hypertension in 1GR group , Coronary plaque score and multi-vessel disease were higher than NGR group; hsC-RP was positively correlated with WBC count, BMI and TG, negatively correlated with HDL-C; WBC count positively correlated with BMI and UA; Or <0.01. Conclusions PSCHD patients with IGR have significantly increased circulating inflammation index and AS level.