论文部分内容阅读
在组织病变部位和组织修复过程中常伴有纤维增生。在受损伤的组织中,局部结缔组织的胶原形成增加,纤维成份过剩并沉着形成瘢痕,称为纤维化;局部组织的进行性纤维化向脏器漫延,导致受累脏器的机能障碍,称为纤维增生症,如肝纤维化、类风湿性关节炎等。在纤维增生过程中有成纤维细胞(Fb)聚集,与免疫细胞的趋化现象相似。Fb的趋化、激活、增殖及其调节皆受淋巴因子及单核因子的制约。近年来,纤维增生与免疫的关系已有不少报道,确定了参与Fb趋化、激活、增殖和促进胶原形成的多种细胞因子。
In the tissue lesions and tissue repair process often accompanied by fibrosis. In injured tissue, local connective tissue collagen formation increases, excessive fiber composition and the formation of scar formation, known as fibrosis; local tissue of the progressive fibrosis spread to the organs, resulting in impaired organ dysfunction, known as Fibrosis, such as liver fibrosis, rheumatoid arthritis and so on. Fibroblasts (Fb) accumulate during fibrogenesis, similar to immune cell chemotaxis. Chemotaxis, activation, proliferation and regulation of Fb are regulated by lymphokines and monokines. In recent years, there has been a lot of reports on the relationship between fibrogenesis and immunity, and many cytokines involved in Fb chemotaxis, activation, proliferation and promotion of collagen formation have been identified.