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观察了单脉冲低频率电刺激大鼠纹状体（ＣＰｕ）和黑质网状部（ＳＮＲ）注射Ｐ物质（ＳＰ，２．５μｇ／０．０５μｌ），对丘脑腹内侧核（ＶＭ）自发放电频率的影响。结果是：（１）电刺激ＣＰｕ使大多数ＶＭ神经元兴奋（１６／１８）；（２）ＳＮＲ注ＳＰ使大多数神经元抑制（１５／１９）；（３）大多数神经元（１１／１５）对电刺激ＣＰｕ表现兴奋的同时，对ＳＮＲ注ＳＰ表现抑制。提示电刺激ＣＰｕ触发了纹体—黑质ＧＡＢＡ的释放，ＧＡＢＡ与ＳＰ在黑质水平共同调节黑质—ＶＭＧＡＢＡ通路，前者抑制，后者兴奋。
The effects of single pulse low frequency electrical stimulation on substance SP (2.5μg / 0.05μl) in rat striatum (CPu) and substantia nigra mesh (SNR) were observed. Spontaneous discharges of the ventromedial thalamus The impact of frequency. The results were: (1) electrical stimulation of CPu stimulated most VM neurons (16/18); (2) SNR injection of SP suppressed most neurons (15/19); (3) most neurons (11 / 15) CPu stimulation of electrical stimulation at the same time, the performance of SNR injection of SP inhibition. Tip electrical stimulation CPu triggers the release of the striatum - substantia nigra GABA, GABA and SP in the substantia nigra level together regulate the substantia nigra-VMGABA pathway, the former inhibition, the latter excited.