幽门螺杆菌（ Hp）是引起消化系统疾病（如消化性溃疡、胃癌及胃黏膜相关淋巴组织淋巴瘤等）的主要病原菌。目前Hp的治疗方案主要是药物抗菌疗法，但此法存在复发率高、难以群体防治的不足，而Hp疫苗有望解决这一问题，但目前尚未找到高效、安全的Hp疫苗。近年来Hp 疫苗在实验研究、免疫机制、免疫佐剂与呈递系统及临床研究等方面均取得了较大进展。“,”Helicobacter pylori(Hp) is the main cause of digestive diseases such as peptic ulcer,gastric carcinoma and mucosa-associated lymphoid tissue lymphoma.At present, the eradication therapy mainly depends on antibiotics,which has the disadvantages of high recurrence and difficult for population control .Hp vaccine is expected to be able to solve the problems,though there isn′t an efficient and safe vaccine discov-ered so far.Great progress in the experiment research,immunologic mechanism,adjuvant immunotherapy, delivery system and clinical trials of Hp vaccine in recent years.