胰岛素样生长因子-I(IGF-I)是一种重要的组织生长因子,具有类胰岛素及促有丝分裂的作用。IGF-I通过与其受体结合产生生物学效应,并受IGF-I结合蛋白调节。正常妊娠母血及脐血IGF-I水平均有升高,而在各种病理妊娠其变化不同,提示IGF-I对妊娠及其相关疾病的发生发展有重要意义。 Insulin-like growth factor-I (IGF-I) is an important tissue growth factor that has insulin-like and mitogenic effects. IGF-I exerts a biological effect by binding to its receptor and is regulated by IGF-I binding proteins. The levels of IGF-I in normal pregnant and umbilical blood are all increased, but their changes in various pathological pregnancies are different, suggesting IGF-I is important for the occurrence and development of pregnancy and its related diseases.