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根据天花粉蛋白（Tk）作用了淋巴细胞体外增殖的抑制是否由CD8细胞所介导,健康人群被分成介导型（M~+）和非介导型（M~-）两类。我们已有的工作证明,性状M~+/M~-由HLA连锁的一对孟德尔基因控制。本文采用分子生物学手段,对M~+”和M~-个体作HLAⅡ类基因的精细分型,发现编码DQ异二聚体分子的DQA和DQB两个基因同时决定M~+的表达,而且等位基因DQA1*0501和DQB1*0201以顺式和反式两种形式发挥互补作用,从而把人体中调控Tk免疫应答的遗传成份直接定位在该特定DQ分子的编码基因上。这一互补现象同时解释了DR3、DR5和DR7与M~+呈现次级关联的复杂格局。
According to whether Tk inhibits the in vitro proliferation of lymphocytes mediated by CD8 cells, healthy individuals are divided into two types: M ~ + and M ~. Our work has shown that the trait M ~ + / M ~ - is controlled by a pair of Mendelian genes linked by HLA. In this paper, we used molecular biology to classify HLA class II genes into M ~ + "and M ~ - individuals and found that DQA and DQB genes encoding DQ heterodimers simultaneously determine M ~ + expression, and The alleles DQA1 * 0501 and DQB1 * 0201 play a complementary role in both cis and trans forms, directing the genetic component of the Tk immune response in the human body to the encoded gene of that particular DQ molecule. This complementation At the same time, we explain the complex pattern that DR3, DR5 and DR7 appear secondary association with M ~ +.