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上海交通大学系统生物医学研究院吴方课题组通过构建创新的高通量气体检测方法,发现了第一个硫化氢气体信号通路关键酶CBS的高效特异抑制剂。相关成果发表在英国皇家化学会《化学通讯》杂志上。据了解,一氧化氮、一氧化碳和硫化氢被认为是细胞内的气体信号分子。上世纪末,一氧化氮气体信号通路的分子机理研究,最终促成“伟哥”药物的成功发现。硫化氢的产生则主要通过CBS和CSE维生素B6依赖酶,但其信号通路的具体分子机理不是很清楚。同时,CBS和CSE酶最近被认为和癌症、唐氏综合征等疾病密切相关。
Wu Fang, Department of System Biomedical Research, Shanghai Jiao Tong University, discovered an efficient and specific inhibitor of CBS, the first key enzyme in H2S signaling, through the construction of an innovative high-throughput gas detection method. Relevant results published in the British Royal Society Chemical News magazine. It is understood that nitric oxide, carbon monoxide and hydrogen sulfide are considered as intracellular gas signaling molecules. The end of the last century, the molecular mechanism of nitric oxide gas signaling pathway eventually led to the successful discovery of “Viagra” drugs. The production of hydrogen sulfide mainly through CBS and CSE vitamin B6 dependent enzymes, but the specific molecular mechanism of its signaling pathway is not very clear. In the meantime, CBS and CSE enzymes are recently thought to be closely linked to diseases such as cancer and Down Syndrome.