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检测１６例ＨＤＶ（＋）重肝患者ＰＢＭＣ膜上ＩＬ－２Ｒ、培养上清和血清中ｓＩＬ－２Ｒ含量，以２１例ＨＤＶ（－）重肝为疾病对照，２０例献血员为正常对照，探讨ＩＬ－２Ｒ在丁型肝炎中变化意义。结果：ＨＤＶ（＋）组ＩＬ－２Ｒ表达虽增强，但不如ＨＤｖ（－）组明显；ｓＩＬ－２Ｒ含量，两重肝组均非常显著增高，但之间无差异。提示ＨＤＶ（＋）重肝组Ｔ淋巴细胞被激活状态并未因增加ＨＤＶ感染而加重，支持丁型肝炎肝损伤主要不是免疫介导的观点。
Serum levels of IL-2R and IL-2R in PBMC of 16 patients with HDV (+) severe hepatitis were detected. Twenty-one patients with HDV (-) severe liver disease as controls and 20 blood donors as controls were enrolled. -2R in hepatitis D changes. Results: Compared with HDv (-) group, the expression of IL-2R in HDV (+) group was significantly higher than that in HDv (-) group. The content of sIL-2R in both HDL group and control group was significantly increased. These results suggest that the activation of T lymphocytes in HDV (+) severe hepatitis group is not aggravated by the increase of HDV infection, and the support of hepatitis D liver injury is not mainly immune mediated.