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本文应用微核试验方法对亚硒酸钠(Na_2SeO_3)拮抗氯化高汞(HgCl_2)致小白鼠骨髓嗜多染红细胞的微核作用进行了研究,其主要结果为:(1)Na_2SeO_3(lmg/kg)可显著地降低HgCl_2(lmg/kg)致微核作用(P<0.001);(2)Na_2SeO_3(lmg/kg)在HgCl_2染毒前2h内给予时,其微核率均较单纯HgCl_2对照组为低,但提前4h给予则未显示拮抗作用;(3)Na_2SeO_3在HgCl_2染毒后的30min内给予时具有一定的拮抗致微核作用;(4)给予小白鼠自由饮用含Na_2SeO_3(5mg/L)水一个月后也可明显地减少HgCl_2的致微核作用。
In this paper, micronucleus test was used to study the effect of sodium selenite (Na_2SeO_3) on micronuclei of mouse bone marrow polychromatic erythrocytes induced by high mercury (HgCl_2) in mice. The main results are as follows: (1) Na_2SeO_3 (lmg / kg) significantly reduced the micronuclei induced by HgCl2 (lmg / kg) (P <0.001). (2) When administered within 2h before HgCl2 exposure, Na 2 SeO 3 (lmg / kg) (3) Na_2SeO_3 had certain antagonistic micronuclei effect when administered within 30 min of HgCl 2 exposure; (4) mice were allowed to drink Na_2SeO_3 (5 mg / L) water can also significantly reduce the micronuclei caused by HgCl 2 after one month.