为探讨乙肝疫苗接种后无弱应答的发生机制，在以往流行病学研究的基础上，对２０ 例无（ 弱） 应答者的ＩＬ－ ２活性水平进行了检测。结果无弱应答者的ＩＬ－ ２ 活性水平为（７４ ．５ ±２１ ．４） ，明显低于强应答者的（２９８ ．０ ±５０ ．３）（ Ｐ＜ ０ ．０１） ；且在强应答者中发现，接种乙肝疫苗后的抗－ ＨＢｓ 滴度与ＩＬ－ ２ 活性水平呈正相关，表明无（ 弱） 应答的发生除与接种条件、宿主的一般因素有关外，还与体内的ＩＬ－ ２ 活性水平有关 To investigate the mechanism of no weak response after hepatitis B vaccination, the levels of IL-2 in 20 non-responders (non-responders) were detected based on previous epidemiological studies. Results The level of IL-2 activity in non-responders was (74.5 ± 21.4), significantly lower than that in responders (298 ± 0.53) (P <0.01) The results showed that the titer of anti - HBs after vaccination with hepatitis B vaccine was positively correlated with the level of IL - 2 activity, indicating that the occurrence of no (weak) response was related to the inoculation conditions and the general factors of the host, but also to IL - 2 Activity level