颅神经嵴细胞(cranial neural crest cells,CNCC)起源于背侧神经管,是一个对颅颌面部各种软硬组织的衍生都具有十分重要作用的细胞群。其产生后便向腹侧迁移,并向多种方向进行分化,如骨细胞、神经元细胞、神经胶质细胞、色素细胞、肌细胞等等[1],而这些细胞则进一步组织构建成颅颌面大部分的软硬结缔组织,因此,颅神经嵴细胞对于颅颌面发育具有十分重要的意义。颅神经嵴细胞迁移的启动、迁移 Cranial neural crest cells (CNCC) originate from the dorsal neural tube and are a cell population that plays an important role in the derivation of various soft and hard tissues in craniomaxillofacial region. After its generation, it migrates to the ventral side and differentiates into many directions, such as bone cells, neurons, glial cells, pigment cells, muscle cells, etc. [1], and these cells are further organized into cranial Most of the maxillofacial soft and hard connective tissue, therefore, Cranial neural crest cells for craniomaxillofacial development is of great significance. Cranial neural crest cell migration is initiated and migrated