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目的:研究同型半胱氨酸(HCY)及胱抑素C(CysC)在妊娠糖尿病患者早期肾功能损伤诊断中的临床应用价值。方法:197例妊娠糖尿病患者为观察组,157例健康孕妇为对照组1,138例健康体检非孕女性为对照组2,比较各组HCY及CysC血清浓度,并比较观察组不同24 h尿蛋白(UAER)孕妇的HCY及CysC血清浓度。结果:观察组与对照组1、对照组2比较,HCY、CysC差异有统计学意义(P<0.05),BUN、Cr差异无统计学意义(P>0.05);观察组血清HCY、CysC随UAER的升高而升高,差异均有统计学意义(均P<0.05);观察组HCY、CysC与UAER呈正相关(分别为r=0.526,P<0.05;r=0.581,P<0.05)。结论:HCY、CysC对妊娠糖尿病患者的早期肾功能有较好的监测作用。
Objective: To investigate the clinical value of homocysteine (HCY) and cystatin C (CysC) in the diagnosis of early renal dysfunction in gestational diabetes mellitus. Methods: 197 cases of gestational diabetes mellitus were observed, 157 cases of healthy pregnant women as control group 1,138 healthy non-pregnant women as control group 2, the serum concentrations of HCY and CysC in each group were compared, and the 24-hour urinary protein (UAER) ) HCY and CysC serum concentrations in pregnant women. Results: The difference of HCY and CysC between the observation group and control group 1 and control group 2 was statistically significant (P <0.05), but there was no significant difference between BUN and Cr (P> 0.05) (All P <0.05). There was a positive correlation between HCY, CysC and UAER in the observation group (r = 0.526, P <0.05; r = 0.581, P <0.05). Conclusion: HCY and CysC have a good monitoring effect on the early renal function in gestational diabetes mellitus patients.