论文部分内容阅读
目的:探讨磁共振动态增强扫描(DCE-MRI)定量参数和表观扩散系数(ADC)对前列腺癌的临床诊断价值及ADC与血清前列腺特异抗原(PSA)、α-甲基酰基辅酶A消旋酶(P504S)的相关性。方法:选取本院2012年4月至2015年7月确诊为前列腺病变的60例患者为研究对象,其中前列腺癌32例(前列腺癌组),前列腺增生28例(前列腺增生组)。所有患者均进行常规磁共振检查、DCE-MRI及扩散加权成像(DWI)检查。同时选取30例健康者(正常组)进行常规磁共振检查作为对照。比较3组患者的DCE-MRI定量参数、DWI信号强度值和ADC值,血清PSA、P504S表达情况以及ADC与PSA、P504S的相关性。结果:3组患者的DCE-MRI定量参数相比,前列腺癌组最高,正常组最低,3组差异显著(P<0.05)。前列腺癌患者随着扩散敏感系数(b值)的升高,DWI信号强度增加,ADC值则表现为低信号;前列腺增生组随着b值的升高,DWI信号强度变化不显著,而正常组则随着b值的升高,DWI信号强度降低,且前列腺增生组和正常组的ADC值均表现为高信号,3组差异显著(P<0.05)。前列腺癌组和前列腺增生组的患者PSA表达水平无显著差异(P>0.05),而P504S表达前列腺癌组显著高于前列腺增生组(P<0.05)。相关性分析显示ADC值与PSA、P504S均呈显著负相关(P<0.05)。结论:DCE-MRI可用于前列腺癌的诊断及鉴别;ADC值与前列腺的特异性抗原PSA、P504S呈显著负相关,其测量有助于对前列腺癌的生物学特性进行初步评估。
Objective: To investigate the diagnostic value of DCE-MRI quantitative parameters and apparent diffusion coefficient (ADC) in prostate cancer and the relationship between ADC and serum PSA, Correlation of enzyme (P504S). Methods: Sixty patients diagnosed as prostate lesions from April 2012 to July 2015 were selected as study subjects, including 32 cases of prostate cancer (prostate cancer group) and 28 cases of benign prostatic hyperplasia (BPH group). All patients underwent routine magnetic resonance imaging, DCE-MRI and diffusion-weighted imaging (DWI). At the same time select 30 healthy people (normal group) for routine magnetic resonance examination as a control. DCE-MRI quantitative parameters, DWI signal intensity and ADC value, serum PSA, P504S expression and ADC and PSA, P504S were compared between the three groups. Results: Compared with the quantitative parameters of DCE-MRI in the three groups, the highest in prostate cancer group and the lowest in normal group were significant (P <0.05). With the increase of b value, the signal intensity of DWI increased and the ADC value showed a low signal in prostatic cancer patients. The signal intensity of DWI did not change significantly with the increase of b value in prostatic hyperplasia group, The DWI signal intensity decreased with the increase of b value, and the ADC value of benign prostatic hyperplasia group and normal group showed high signal, the difference of 3 groups was significant (P <0.05). There was no significant difference in PSA expression between prostate cancer group and benign prostatic hyperplasia group (P> 0.05), but P504S was significantly higher in prostate cancer group than in benign prostatic hyperplasia group (P <0.05). Correlation analysis showed that ADC value was negatively correlated with PSA, P504S (P <0.05). Conclusion: DCE-MRI can be used for the diagnosis and differential diagnosis of prostate cancer. The value of ADC is negatively correlated with prostate specific antigen PSA and P504S, which may contribute to the preliminary assessment of the biological characteristics of prostate cancer.