本文以玻碳电极为基体,制备了Nafion修饰电极,研究了非电活性阳离子药物地尔硫在该电极上的测定原理及方法。将地尔硫加入到含电活性阳离子药物多巴胺的电解质溶液中,　使多巴胺峰电流下降,峰电流的降低与地尔硫的浓度对数在1.2×10～(-7)～8.0×10～(-6)mol/L范围内呈良好线性关系,本方法检测下限为6.2 ×10～(-8)mol/L;回收率范围为95.8％～104.9％;相对标准偏差为3.1％(n=10)。 In this paper, glassy carbon electrode as the substrate, prepared Nafion modified electrode, non-electroactive cationic drug diltiazem in the electrode determination principle and method. Diltiazem was added to the electrolyte solution containing the electroactive cationic dopamine to decrease the dopamine peak current. The logarithm of the decrease of peak current to diltiazem was between 1.2 × 10 -7 ~ 8.0 × 10 ~ (-6) mol / L, the detection limit of this method was 6.2 × 10 -8 mol / L, the recoveries ranged from 95.8% to 104.9%, and the relative standard deviations were 3.1% (n = 10).