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对氯喹产生抗药性的恶性疟流行区一般都以法西达(Fansider,含乙胺嘧啶25mg,周效磺胺500mg)作为治疗的首选药。在泰国,通常使用单剂2或3片法西达能使80～90%患者得到控制症状。1979年11月,约有33,000名自南部泰柬边境进入的高棉难民。经血片检查,证实其中25%的难民患有疟疾,于是普遍采用单剂“法西达”或单剂“法西达”加用硫酸奎宁三日疗法治疗。1～2周后,不少患者再度发热或体温持续不退,对该类患者进行血片复查,仍可找到恶性疟原虫,说明治疗失效。作者认为由于当时正值旱季,不可能为再度感染。为了研究这些恶性疟患者
Chloroquine-resistant endemic areas of Plasmodium falciparum are generally the first choice for treatment with Fansider (pyrimethamine 25mg, potent sulfonamides 500mg). In Thailand, usually 80 to 90% of patients receive symptom control using a single dose of 2 or 3 tablets of fastigac. In November 1979, there were about 33,000 Khmer refugees entering from the southern Thai-Cambodian border. A blood test, confirming that 25% of refugees have malaria, is generally treated with a single dose of “Faridag” or a single dose of “Faridas” plus quinine sulfate. After 1 to 2 weeks, many patients re-fever or body temperature continued to retreat, blood film review of such patients can still find Plasmodium falciparum, indicating treatment failure. The author believes that due to the dry season at the time, it is impossible to re-infection. In order to study these falciparum malaria patients