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目的:通过观察实验家兔血液流变学变化,探讨柴瓜消结汤治疗乳腺增生病的机理。方法:选用健康新西兰 家兔40只,随机分为空白对照组、模型对照组、柴瓜消结汤大、中、小剂量组,每组8只,采用苯甲酸雌二醇建立乳腺增 生动物模形,分别灌服不同剂量柴瓜消结汤生药提取液予以治疗,空白对照组灌服生理盐水,模型对照组灌服蒸馏 水。结果:模型对照组与空白对照组家兔相比,其全血粘度、血浆粘度、血沉比显著增加(P<0.05),而压积显著减少 (P<0.05):柴瓜消结汤各剂量组家兔全血粘度、血浆粘度、血沉和压积均回复到空白对照组正常水平,与模型对照组 相比差异显著(P<0.05)。结论:柴瓜消结汤可改变实验动物的血流变性,表明活血通络作用是柴瓜消结汤治疗和预 防乳腺增生病的机理之一。
Objective: To observe the mechanism of hyperplasia of mammary gland hyperplasia by observing blood rheology of experimental rabbits. METHODS: Forty healthy New Zealand rabbits were randomly divided into blank control group, model control group, and large, medium and small doses of Scutellariae Xiaojie Decoction, 8 in each group. Mammary hyperplasia was established using estradiol benzoate. Shaped, respectively, fed different doses of Chayotexiaojie Tang crude drug extract to be treated, blank control group gavage saline, model control group fed distilled water. RESULTS: Compared with rabbits in the blank control group, the whole blood viscosity, plasma viscosity, and ESR of the model control group were significantly increased (P<0.05), while the compression volume was significantly reduced (P<0.05): each dose of Chaguaru Xiaojie Decoction Rabbits’ whole blood viscosity, plasma viscosity, ESR, and uterine pressure all returned to the normal level in the blank control group, which was significantly different from the model control group (P<0.05). Conclusion: Chaigua Xiaojie Decoction can change the blood rheology of experimental animals, indicating that Huoxuetongluo is one of the mechanisms for the treatment and prevention of mammary gland hyperplasia.