给予啮齿动物β-甘油磷酸盐可显著地增加肝脏和胆汁的磷脂而不影响胆汁中胆酸和胆固醇的含量。在小鼠实验中观察到由β-甘油磷酸盐使磷脂增高,进而使胆固醇性结石溶解,因而推论其临床的意义重大。但未见β-甘油磷酸盐的长期毒性研究报导,为此作者探讨了β-甘油磷酸盐的大鼠长期毒性试验。作者选用体重为220～225克的雄性Wistar大鼠进行了实验,分为二组,每组动物9只。分别喂饲普通的基础大鼠饲料和含有2.5%β-甘油磷酸盐的同一饲料共33周。从计算饲料消 Administration of beta-glycerophosphate to rodents significantly increased phospholipids in the liver and bile without affecting bile acid and cholesterol levels. It has been observed in mouse experiments that phospholipid is increased by β-glycerophosphate, which in turn dissolves cholesterol calculus. Therefore, it is of great clinical significance. However, long-term toxicity studies of beta-glycerophosphate have not been reported. To this end, the authors explored the long-term toxicity of beta-glycerophosphate in rats. The authors selected male Wistar rats weighing 220-225 g to conduct experiments, divided into two groups of nine animals per group. The normal basal diet and the same diet containing 2.5% beta-glycerophosphate were fed for 33 weeks, respectively. From the calculated feed consumption