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目的 :研究原癌基因 c- myc、抑癌基因 p5 3及 nm2 3过度表达在同一卵巢肿瘤中的变化及临床意义。方法 :用免疫组化 L SAB方法检测 5例正常卵巢组织和 35例卵巢肿瘤组织中的c- myc、p5 3和 nm2 3蛋白的表达水平。结果 :从良性卵巢囊腺瘤、交界性到恶性卵巢囊腺癌 ,c-myc、p5 3及 nm 2 3阳性表达呈增高趋势。其阳性表达率与卵巢肿瘤的细胞增殖状态、肿瘤分化及临床分期有关。 nm2 3表达与淋巴结转移呈负相关。结论 :检测卵巢肿瘤中 c- myc及 p5 3、nm2 3基因表达可了解卵巢囊腺癌的发生、发展 ,找出原癌基因及抑癌基因表达与卵巢肿瘤生物学行为间的关系。
Objective: To study the changes and clinical significance of the overexpression of proto-oncogene c-myc, tumor suppressor gene p53 and nm23 in the same ovarian tumor. Methods: The expression of c-myc, p53 and nm23 in 5 normal ovarian tissues and 35 ovarian tumor tissues was detected by immunohistochemical L SAB method. RESULTS: From benign ovarian cystadenoma to borderline ovarian cancer, the positive expression of c-myc, p53, and nm23 was increased. The positive expression rate is related to cell proliferation, tumor differentiation and clinical stage of ovarian tumors. There was a negative correlation between nm23 and lymph node metastasis. Conclusion : Detecting the expression of c-myc and p53 and nm23 in ovarian cancer can understand the occurrence and development of ovarian cystadenocarcinoma, and find out the relationship between the expression of proto-oncogene and tumor suppressor gene and biological behavior of ovarian tumor.